Bioaktive Oberflächenbeschichtung von bioinerter oxidischer Keramik zur Stimulation der Knochenanbindung

Bioactive surface coating of bioinert oxide ceramics to stimulate osteointegration

The aim of this research project is the production of ceramic implant materials with improved osteointegration. The improvement shall lead to a shortened post-operative healing phase and a solid and long-term integration to the adjacent bone tissue. Surface coating of ceramic implants will be achieved using "wet powder-spray coating" of yttrium stabilized zirconium oxide bioinert (TZ) with mixed suspension consisting of TZ, hydroxyapatite (HA) and magnesium oxide (MgO). The driving idea behind these coatings is that they consist of a solid and non-absorbable part (TZ) and partially absorbable and bioactive components (HA and Mg). this amalgam would provide sufficient biomechanical strength and the vital support of bone cells during healing and bone growth. Biocompatibility was proven through a comprehensive physicochemical and biological examination in vitro. In the current project, the in vivo characterization is being carried out. Here it is expected that the coated TZ-implants will reflect the in vitro results and exhibit enhanced bone formation in vivo, with an increased stability of the implant. The study will utilize an established animal model of rabbits to study biocompatibility and osteointegration. The bone formation will be evaluated histologically and histomorphometrically at the bone implant contact (BIC) region. Additionally biomechanical competence will be determined and compared to the non coated implant controls.